NVIDIA and U.S. Government Launch Genesis Mission to Boost AI Infrastructure and R&D

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Updated Date: December 19, 2025
Written by Kapil Kumar
NVIDIA and U.S. Government Launch Genesis Mission to Boost AI Infrastructure

As a participant in the Genesis Mission within the U.S. Department of Energy (DOE), NVIDIA will be a private industry partner to ensure that U.S. AI remains the leader and the standard in technology worldwide.

One of the executive orders signed by President Trump recently, through the Genesis Mission, is the drive to redefine American leadership in AI in three critical aspects: energy, scientific research, and national security. NVIDIA will provide services to the Department to incorporate a discovery platform that integrates the U.S. government, industry, and academia.

The officials of the DOE anticipate that the Genesis Mission will enhance the productivity and contributions of American science and engineering and provide American energy hegemony, quick scientific discovery, and boost the security of the nation.

The NVIDIA and the DOE are already making historic performances in the critical fields, which include:

  • OpenAI science models, including the NVIDIA Apollo family, to develop weather forecasting, computational fluid dynamics, and structural mechanics.
  • Optimising manufacturing and supply chain processes with AI.
  • Robotics, edge AI, and autonomous laboratories, such as with the help of high-fidelity simulation and AI-enabled digital twins.
  • Nuclear power, fission, and fusion research.
  • The development of quantum computers, where supercomputers and AI are used to speed up the development of new algorithms.
  • Healthcare biology, materials science, and synthetic design; and critical-materials breakthroughs.

NVIDIA and DOE Announce MOU

Moreover, NVIDIA declared that the company signed the memorandum of understanding (MOU) with the Department to outline priorities of the partnership to accelerate the process of scientific discovery.

The MOU covers, but is not confined to, AI in manufacturing and supply chain, open-source AI, fission energy, robotics, AI-enabled digital twins, fusion energy, quantum computing, and science.

These priorities, together, are concerned with applying advanced AI, robotics, and high-performance computing to revolutionise energy, manufacturing, and scientific discovery through the Department of Energy mission space. They highlight AI-driven design, control, and management of complex systems, including nuclear fission and fusion reactors, experimental systems, digital twins of infrastructure, and autonomous laboratories, including on the edge to make decisions in real time.

Further collaborations can be made in the areas of faster breakthroughs in quantum computing, material science, biology, and synthetic design; underground and geothermal resources; environmental cleanup; and open science-optimised AI models and AI co-scientists that accelerate the creation of algorithms and code generation in high-level scientific problems.

The support of the Genesis Mission by NVIDIA follows a number of partnerships between NVIDIA and the DOE that have been established at the NVIDIA GTC Washington, D.C., conference, such as NVIDIA and Oracle developing the largest supercomputer ever built by the department at Argonne National Laboratory. This can be added to the news that NVIDIA will help serve seven new systems in both Argonne and Los Alamos National Laboratories, which will accelerate the DOE mission of technological leadership.

The accelerated computing architecture invented by NVIDIA to enable modern AI is a platform that lets researchers use it to train super-large models, model physical systems, and further science at unprecedented scale and speed.

The U.S. and the rest of the world are experiencing a new industrial revolution due to AI. The Genesis Mission is likely to spread and speed up that revolution.